Lausanne ▸ Prague
Prague ▸ Lausanne ⇄1.9 a dayfastest 12h15☾ 2 overnight busesFlixBus🇨🇭 Switzerland → 🇨🇿 Czechia
Direct buses · no change
LausanneBernZurichSt. GallenBregenzLindauPrague· 699 km as the crow flies
- 00:55 → 14:35FlixBus N106 ☾ OvernightLausanne (P+R Vélodrome) → Prague (Main Railway Station) · via Bern, Zurich, St. Gallen, Bregenz…13h407 stopsRuns: Mon, Tue, Wed, Sat, Sun (some weeks)The night the clocks change (Sun 25 Oct: 00:55 → 13:35)Book on FlixBus ↗
- 21:05 → 09:20+1FlixBus N872 ☾ OvernightLausanne (P+R Vélodrome) → Prague (Central Bus Station Florenc) · via Bern, Basel, Freiburg, Nuremberg12h154 stops
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Lausanne to Prague?
Yes. 1.9 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Lausanne to Prague?
The fastest takes 12h15; the slowest 13h40, for 699 km as the crow flies.
When do the buses leave?
The earliest leaves at 00:55 and the latest at 21:05, local time in Lausanne. Not every bus runs every day: pick a date above.
Is there a night bus from Lausanne to Prague?
Yes: 2 overnight departures in the timetable, for example 00:55 arriving 14:35.