Lyon to Prague bus: 3.3 a day, fastest 15h15

3.3 a dayfastest 15h15☾ 3 overnight busesFlixBus🇫🇷 France → 🇨🇿 Czechia

Direct buses · no change

LyonChalon-sur-SaôneBelfortMulhouseColmarStrasbourgPrague· 860 km as the crow flies

05:20 → 21:50
FlixBus N1316
Lyon (Gerland Bus Station) → Prague (Central Bus Station Florenc) · via Chalon-sur-Saône, Besançon, Strasbourg, Karlsruhe…
16h3012 stops
Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
18:05 → 09:20⁺¹
FlixBus N1759 ☾ Overnight
Lyon (Gerland Bus Station) → Prague (Central Bus Station Florenc) · via Dole, Besançon, Montbéliard, Belfort…
15h158 stops
Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 18:05 → 08:20+1)Book on FlixBus ↗
21:30 → 14:35⁺¹
FlixBus N106 ☾ Overnight
Lyon (Gerland Bus Station) → Prague (Main Railway Station) · via Geneva, Lausanne, Bern, Zurich…
17h059 stops
Runs: Mon, Tue, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 21:30 → 13:35+1)Book on FlixBus ↗
22:00 → 15:25⁺¹
FlixBus N1315 ☾ Overnight
Lyon (Gerland Bus Station) → Prague (Central Bus Station Florenc) · via Chalon-sur-Saône, Belfort, Mulhouse, Colmar…
17h2514 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 22:00 → 14:25+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 18:05, arrive 09:20

The plane is 10h50 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct16h00

To Lyon (Gerland Bus Station)17 min
At the stop before departure15 min
FlixBus N175915h15
From Prague (Central Bus Station Florenc)13 min

Plane · nonstop LYS to PRG5h10

To Lyon–Saint-Exupéry (LYS)50 min
Check-in & security1h30
Flight LYS to PRG1h55
Landing to exit20 min
From PRG35 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance.

Train instead?

No direct train from Lyon to Prague in pickthetrain's timetables: the bus is the no-change way.

Where Lyon goes by direct train ↗

Flying instead?

2 airlines fly Lyon to Prague nonstop. Book on the airline's own site:

VoloteaLYS→PRGBook direct ↗
easyJetLYS→PRGBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Lyon to Prague?

Yes. 3.3 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Lyon to Prague?

The fastest takes 15h15; the slowest 17h25, for 860 km as the crow flies.

When do the buses leave?

The earliest leaves at 05:20 and the latest at 22:00, local time in Lyon. Not every bus runs every day: pick a date above.

Is there a night bus from Lyon to Prague?

Yes: 3 overnight departures in the timetable, for example 18:05 arriving 09:20 the next morning.

Lyon ▸ Prague

Direct buses · no change

Quick answers

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