Mainz to Prague bus: 1 a day, fastest 8h25

1 a dayfastest 8h25FlixBus🇩🇪 Germany → 🇨🇿 Czechia

Direct buses · no change

MainzFrankfurtErlangenNurembergPrague· 439 km as the crow flies

16:20 → 00:45⁺¹
FlixBus N1310
Mainz central train station (exit West) → Prague (Main Railway Station) · via Frankfurt, Erlangen, Nuremberg
8h254 stops
Runs: DailyBook on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

Fastest door to door: the plane (4h35). The bus takes 4h34 longer.

Bus · fastest direct9h09

To Mainz central train station (exit West)16 min
At the stop before departure15 min
FlixBus N13108h25
From Prague (Main Railway Station)13 min

Plane · nonstop FRA to PRG4h35

To Frankfurt (FRA)55 min
Check-in & security1h30
Flight FRA to PRG1h15
Landing to exit20 min
From PRG35 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance.

Flying instead?

3 airlines fly Mainz to Prague nonstop. Book on the airline's own site:

Air DolomitiFRA→PRGBook direct ↗
CondorFRA→PRGBook direct ↗
LufthansaFRA→PRGBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Mainz to Prague?

Yes. 1 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Mainz to Prague?

The fastest takes 8h25; the slowest 8h25, for 439 km as the crow flies.

Is there a night bus from Mainz to Prague?

Not an overnight one: every bus here travels by day or evening.

Mainz ▸ Prague

Direct buses · no change

Quick answers

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