Milan to Lyon bus: 12.2 a day, fastest 6h10

12.2 a dayfastest 6h10☾ 4 overnight busesBlaBlaCar Bus, FlixBus🇮🇹 Italy → 🇫🇷 France

Direct buses · no change

MilanAostaCourmayeurChamonixAnnecyLyon· 339 km as the crow flies

05:45 → 12:00
FlixBus N406
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin
6h151 stop
Runs: DailyThe night the clocks change (Sun 25 Oct: 04:45 → 11:00)Book on FlixBus ↗
07:30 → 14:10
FlixBus 726
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Saint-Jean-de-Maurienne
6h402 stops
Runs: DailyBook on FlixBus ↗
08:30 → 15:05
FlixBus 1729
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Chambéry
6h352 stops
Runs: DailyBook on FlixBus ↗
09:15 → 16:25
FlixBus 729
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Chambéry
7h102 stops
Runs: DailyBook on FlixBus ↗
10:20 → 17:05
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Grenoble
6h452 stops
Runs: Thu to SunBook on BlaBlaCar Bus ↗
11:35 → 19:35
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Aosta, Courmayeur, Chamonix, Annecy
8h004 stops
Runs: Thu to SunBook on BlaBlaCar Bus ↗
12:05 → 18:40
FlixBus 1646
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Novara, Turin
6h352 stops
Runs: Daily until Mon 2 NovBook on FlixBus ↗
15:00 → 21:10
FlixBus 480
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Oulx
6h102 stops
Runs: DailyBook on FlixBus ↗
16:00 → 22:50
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Chambéry
6h502 stops
Runs: Only Sun 25 Octthe open data has only these datesBook on BlaBlaCar Bus ↗
16:00 → 22:55
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Chambéry
6h552 stops
Runs: Thu to Sun (some weeks)Book on BlaBlaCar Bus ↗
18:00 → 00:35⁺¹
FlixBus N729
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Oulx, Chambéry
6h353 stops
Runs: DailyBook on FlixBus ↗
18:50 → 01:20⁺¹
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Chambéry
6h302 stops
Runs: Sun (some weeks)Book on BlaBlaCar Bus ↗
20:00 → 02:20⁺¹
BlaBlaCar Bus
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Chambéry
6h202 stops
Runs: Only Sun 25 Octthe open data has only these datesBook on BlaBlaCar Bus ↗
21:35 → 03:55⁺¹
FlixBus N410 ☾ Overnight
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin
6h201 stop
Runs: DailyThe night the clocks change (Sat 24 Oct: 21:35 → 02:55+1)Book on FlixBus ↗
22:30 → 04:50⁺¹
FlixBus N729 ☾ Overnight
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin
6h201 stop
Runs: DailyThe night the clocks change (Sat 24 Oct: 22:30 → 03:50+1)Book on FlixBus ↗
23:35 → 06:45⁺¹
BlaBlaCar Bus ☾ Overnight
Milan - Lampugnano Bus Station → Lyon - Gerland Bus Station · via Turin, Grenoble
7h102 stops
Runs: Thu to Sun (some weeks)The night the clocks change (Sat 24 Oct: 23:35 → 05:45+1)Book on BlaBlaCar Bus ↗
23:45 → 06:30⁺¹
FlixBus N527 ☾ Overnight
Milan (Lampugnano bus station) → Lyon (Gerland Bus Station) · via Turin, Chambéry
6h452 stops
Runs: Daily except TueThe night the clocks change (Sat 24 Oct: 23:45 → 05:30+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

Fastest door to door: the plane (4h40). The bus takes 2h24 longer.

Bus · fastest direct7h04

To Milan (Lampugnano bus station)22 min
At the stop before departure15 min
FlixBus 4806h10
From Lyon (Gerland Bus Station)17 min

Train · fastest direct4h50

To Milano Centrale1 min
Before departure10 min
Frecciarossa4h39

Plane · nonstop MXP to LYS4h40

To Milan Malpensa (MXP)55 min
Check-in & security1h30
Flight MXP to LYS1h05
Landing to exit20 min
From LYS50 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

4.3 a daydirect trains, fastest 4h39

Trenitalia. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

1 airline fly Milan to Lyon nonstop. Book on the airline's own site:

Twin JetMXP→LYSBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Milan to Lyon?

Yes. 12.2 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Milan to Lyon?

The fastest takes 6h10; the slowest 8h00, for 339 km as the crow flies.

When do the buses leave?

The earliest leaves at 05:45 and the latest at 23:45, local time in Milan. Not every bus runs every day: pick a date above.

Is there a night bus from Milan to Lyon?

Yes: 4 overnight departures in the timetable, for example 21:35 arriving 03:55 the next morning.

Milan ▸ Lyon

Direct buses · no change

Quick answers

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