Prague to Milan bus: 1 a day, fastest 12h50

1 a dayfastest 12h50☾ 1 overnight busFlixBus🇨🇿 Czechia → 🇮🇹 Italy

Direct buses · no change

PraguePlzeňRegensburgMunichChurLuganoMilan· 646 km as the crow flies

20:20 → 09:10⁺¹
FlixBus N1308 ☾ Overnight
Prague (Main Railway Station) → Milan (Lampugnano bus station) · via Plzeň, Regensburg, Munich, Chur…
12h506 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:20 → 08:10+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 20:20, arrive 09:10

The plane is 8h44 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct13h39

To Prague (Main Railway Station)12 min
At the stop before departure15 min
FlixBus N130812h50
From Milan (Lampugnano bus station)22 min

Plane · nonstop PRG to MXP4h55

To Václav Havel Airport Prague (PRG)35 min
Check-in & security1h30
Flight PRG to MXP1h35
Landing to exit20 min
From MXP55 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance.

Train instead?

No direct train from Prague to Milan in pickthetrain's timetables: the bus is the no-change way.

Where Prague goes by direct train ↗

Flying instead?

2 airlines fly Prague to Milan nonstop. Book on the airline's own site:

RyanairPRG→BGYBook direct ↗
easyJetPRG→MXPBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Prague to Milan?

Yes. 1 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Prague to Milan?

The fastest takes 12h50; the slowest 12h50, for 646 km as the crow flies.

Is there a night bus from Prague to Milan?

Yes: 1 overnight departure in the timetable, for example 20:20 arriving 09:10 the next morning.

Prague ▸ Milan

Direct buses · no change

Quick answers

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