Karlsruhe ▸ Lugano
Lugano ▸ Karlsruhe ⇄1.6 a dayfastest 6h45☾ 1 overnight busFlixBus🇩🇪 Germany → 🇨🇭 Switzerland
Direct buses · no change
KarlsruheStuttgartZurichAltdorfLugano· 336 km as the crow flies
- 07:40 → 16:10FlixBus 024Karlsruhe central train station → Lugano (Via Ciani) · via Stuttgart, Zurich, Altdorf8h306 stopsRuns: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
- 22:05 → 04:50+1FlixBus N474 ☾ OvernightKarlsruhe central train station → Lugano (Via Ciani) · via Freiburg, Basel, Zurich6h453 stopsRuns: Mon, Tue, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 22:05 → 03:50+1)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Karlsruhe to Lugano?
Yes. 1.6 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Karlsruhe to Lugano?
The fastest takes 6h45; the slowest 8h30, for 336 km as the crow flies.
When do the buses leave?
The earliest leaves at 07:40 and the latest at 22:05, local time in Karlsruhe. Not every bus runs every day: pick a date above.
Is there a night bus from Karlsruhe to Lugano?
Yes: 1 overnight departure in the timetable, for example 22:05 arriving 04:50 the next morning.