Milan to Frankfurt bus: 4.8 a day, fastest 9h35

4.8 a dayfastest 9h35☾ 3 overnight busesFlixBus🇮🇹 Italy → 🇩🇪 Germany

Direct buses · no change

MilanBregenzUlmStuttgartKarlsruheMannheimFrankfurt· 519 km as the crow flies

01:15 → 13:30
FlixBus N77 ☾ Overnight
Milan (Lampugnano bus station) → Frankfurt central train station · via Bregenz, Ulm, Stuttgart, Karlsruhe…
12h155 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 01:15 → 12:30)Book on FlixBus ↗
07:15 → 18:05
FlixBus 476
Milan (Lampugnano bus station) → Frankfurt central train station · via Zurich, Lörrach, Freiburg, Karlsruhe…
10h507 stops
Runs: Mon, Thu, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
11:30 → 22:45
FlixBus 107
Milan (Lampugnano bus station) → Frankfurt central train station · via Zurich, Basel, Freiburg, Rust…
11h157 stops
Runs: DailyBook on FlixBus ↗
19:00 → 05:50⁺¹
FlixBus N07 ☾ Overnight
Milan (Lampugnano bus station) → Frankfurt central train station · via Zurich, Freiburg, Karlsruhe, Heidelberg…
10h508 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 19:00 → 04:50+1)Book on FlixBus ↗
20:25 → 06:00⁺¹
FlixBus N487 ☾ Overnight
Milan (Lampugnano bus station) → Frankfurt central train station · via Basel, Karlsruhe, Mannheim
9h353 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:25 → 05:00+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 20:25, arrive 06:00

The plane is 6h11 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct10h26

To Milan (Lampugnano bus station)22 min
At the stop before departure15 min
FlixBus N4879h35
From Frankfurt central train station14 min

Train · fastest direct7h48

To Milano Centrale1 min
Before departure10 min
EC 1507h34
From Frankfurt(Main)Hbf3 min

Plane · nonstop LIN to FRA4h15

To Milan Linate (LIN)25 min
Check-in & security1h30
Flight LIN to FRA1h25
Landing to exit20 min
From FRA35 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 7h34

Trenitalia. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

4 airlines fly Milan to Frankfurt nonstop. Book on the airline's own site:

Air DolomitiLIN→FRA · MXP→FRABook direct ↗
LufthansaLIN→FRA · MXP→FRABook direct ↗
CondorMXP→FRABook direct ↗
easyJetLIN→FRABook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Milan to Frankfurt?

Yes. 4.8 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Milan to Frankfurt?

The fastest takes 9h35; the slowest 12h15, for 519 km as the crow flies.

When do the buses leave?

The earliest leaves at 01:15 and the latest at 20:25, local time in Milan. Not every bus runs every day: pick a date above.

Is there a night bus from Milan to Frankfurt?

Yes: 3 overnight departures in the timetable, for example 01:15 arriving 13:30.

Milan ▸ Frankfurt

Direct buses · no change

Quick answers

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