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Direct buses › From Siena

Siena ▸ Lyon

Lyon ▸ Siena ⇄
1.2 a dayfastest 12h00☾ 1 overnight busFlixBus🇮🇹 Italy → 🇫🇷 France

Direct buses · no change

SienaPoggibonsiFlorenceBolognaMilanTurinLyon· 580 km as the crow flies
  • 10:40 → 22:40
    FlixBus 516
    Siena (Stazione FS) → Lyon (Gerland Bus Station) · via Florence, Genoa, Turin
    12h003 stops
    Runs: Mon, Thu, Fri, Sat, SunBook on FlixBus ↗
  • 17:25 → 06:30+1
    FlixBus N527 ☾ Overnight
    Siena (Stazione FS) → Lyon (Gerland Bus Station) · via Poggibonsi, Florence, Bologna, Milan…
    13h056 stops
    Runs: Mon, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 17:25 → 05:30+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Siena to Lyon?

Yes. 1.2 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Siena to Lyon?

The fastest takes 12h00; the slowest 13h05, for 580 km as the crow flies.

When do the buses leave?

The earliest leaves at 10:40 and the latest at 17:25, local time in Siena. Not every bus runs every day: pick a date above.

Is there a night bus from Siena to Lyon?

Yes: 1 overnight departure in the timetable, for example 17:25 arriving 06:30 the next morning.

More from Siena

Every bus from Siena

More to Lyon

Every bus from Lyon