Mainz ▸ Milan
Milan ▸ Mainz ⇄6 a weekfastest 12h05FlixBus🇩🇪 Germany → 🇮🇹 Italy
Direct buses · no change
MainzFrankfurtHeidelbergKarlsruheFreiburgLörrachMilan· 507 km as the crow flies
- 07:10 → 19:15FlixBus 476Mainz central train station (exit West) → Milan (Lampugnano bus station) · via Frankfurt, Heidelberg, Karlsruhe, Freiburg…12h059 stopsRuns: Mon, Tue, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Mainz to Milan?
Yes. 6 a week on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Mainz to Milan?
The fastest takes 12h05; the slowest 12h05, for 507 km as the crow flies.
Is there a night bus from Mainz to Milan?
Not an overnight one: every bus here travels by day or evening.