Milan ▸ Mainz
Mainz ▸ Milan ⇄6 a weekfastest 12h15FlixBus🇮🇹 Italy → 🇩🇪 Germany
Direct buses · no change
MilanZurichLörrachFreiburgKarlsruheHeidelbergMainz· 507 km as the crow flies
- 07:15 → 19:30FlixBus 476Milan (Lampugnano bus station) → Mainz central train station (exit West) · via Zurich, Lörrach, Freiburg, Karlsruhe…12h159 stopsRuns: Mon, Thu, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Milan to Mainz?
Yes. 6 a week on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Milan to Mainz?
The fastest takes 12h15; the slowest 12h15, for 507 km as the crow flies.
Is there a night bus from Milan to Mainz?
Not an overnight one: every bus here travels by day or evening.